Physical rehabilitation modulates microRNAs involved in multiple sclerosis: a case report

Annamaria Vallelunga; Carmine Berlingieri; Marco Ragusa; Michele Purrello; Maria Rosaria Stabile; Maria Consiglia Calabrese; Julio Cesar Morales‐Medina; Beniamino Palmieri; and Tommaso Iannitticorresponding

This study shows that neuromuscular taping improves gait, balance, pain and ability to walk and conduct daily activities in a multiple sclerosis patient. It is the first study to identify a panel of miRNAs modulated throughout rehabilitation using neuromuscular taping in a multiple sclerosis patient.

Multiple sclerosis (MS) is a neurodegenerative disease with symptoms including pain, coordination impairment, and muscle weakness 1. Rehabilitation can improve motor function and patients' quality of life (QOL). Neuromuscular taping (NMT) is a new elastic tape which improves muscular function, pain, and postural alignment, increases lymphatic and vascular flow, and strengthens weakened muscles 2. Furthermore, NMT increases leg muscle strength in patients affected by relapsing–remitting MS (RR‐MS) versus sham device 2. The concept of “rehabilomics” aims to study rehabilitation endophenotypes to discover the molecular substrates involved in rehabilitation, but no biomarker is available to determine rehabilitation efficacy. miRNAs are small noncoding RNAs responsible for post‐transcriptional gene regulation 3 and key regulators in MS 4679. In addition, they are modulated by exercise in healthy subjects 58.

In this study, we determined NMT efficacy in a secondary‐progressive MS (SP‐MS) patient and investigated, for the first time, (1) whether circulating miRNAs are altered by NMT and (2) are predictors of successful rehabilitation therapy.

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